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To achieve this, the ester 0.5 M in methanol and hydroxyl amine 10 eq was reacted in the presence of sodium methoxide 1 eq. Following an optimization studies, they found that at 70 and 30 min, highest yield of the hydroxamate was obtained with high purity. Microware Activated Hydroxamic Acid Synthesis Massaro et al 33 has shown that the reaction of esters with hydroxylamine in the presence of a base under microwave activation provides hydroxamic acids in good yield and high purity.

34 Application of ultra-sonication was showed to accelerate this conversion. This process increases the amount of RNA present in the cell and their respective encoded proteins. Synthesis of Trichostatin A Trichostatin A was the first naturally occurring HDI to be discovered. It causes an increase in acetylated histones in a variety of mammalian tumor cell line. 45 Trichostatin A was shown to be a selective histone deacetylase inhibitor, reversibly inhibiting classes I, II and IV types of HDAC while not affecting class III. 46 The first portion of the synthesis is shown in scheme 9. The TBS group was later recovered with tetra- normal-butylammonium fluoride TBAF in THF to give alcohol 28 in 91 yields. The second portion of the synthesis is presented in schemes 10. Hyper acetylation of histones increases the access of some transcription factors to nucleosomes thereby increasing RNA transcription.

Histone deacetylase inhibitors HDI leads to hyper acetylation by blocking the function of histone deacetylase, therefore leaving the lysine amino acids acetylated from the histone acetyl transferase and ultimately increasing transcription. 17, 18 These class of compounds are used in the design of therapeutics targeting cancer 19, 20 e.g. histone deacetylases HDACs inhibitors like vorinostat, belinostat, panobinostat and trichostatin A, 21 cardiovascular diseases 22 e.g. hydroxyurea, 24 Alzheimer s, 25 malaria 26, 27 e.g. Keywords: Keyword Histone deacetylase inhibitors, Matrix metalloproteinase inhibitors, HIV, Hydroxamaates, Ribonucleoside diphosphate reductase Cite this paper: David I. The reasonable way of producing hydroxamic acid derivative is the reaction of hydroxylamine with acid chlorides or esters. 13 Hydroxamic acids are capable of inhibiting a variety of enzymes, including ureases, 14, 15 peroxidises 16, and matrix metalloproteinases. desferrioxamine B, fosmidomycin, siderophores 28 and allergic diseases.

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